Thrombophilia is a disorder of blood coagulation and is defined as the increased susceptibility to pathological blood clot. Thrombophilia is discriminated into two main categories: adaptive and hereditary.
The most common types of heritable thrombophilia are mainly due to:
(a) the increased activity of the coagulation factors due to a change in the genetic material in genes, which have an important role in the mechanism of coagulation-fibrinolysis, and
(b) the absence of natural anticoagulants, such as lack of antithrombin III, protein C or S.