Thrombophilia and Infertility

The role of thrombophilia in infertility and pregnancy

The period of pregnancy is a condition characterized by an increase in blood clotting. Specifically, the levels of clotting factors and the levels of the physiological anticoagulants are increased. These physiological changes are intended to limit blood loss protecting the mother during childbirth. However, these changes during pregnancy in women with inherited thrombophilia increase the risk of clot formation affecting vascularization and blood flow of the placenta and the blood vessels that nourish the fetus.

In recent years, several international studies have associated thrombophilia with an increased risk of miscarriage and complications during pregnancy, such as:

  • failure of embryo implantation,
  • poor endometrial fetal growth,
  • preeclampsia,
  • thrombophlebitis,
  • premature detachment of the placenta.

It is estimated that approximately 40% of cases of women with complications, before and after pregnancy, are due to hereditary thrombophilia.

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